Molecules

All signalling molecules tracked across rare diseases on Kipine, with evidence-linked profiles and cross-disease expression data.

30 molecules tracked

Molecule3 diseases

IL-1β

Central pathogenic driver

Schnitzler Syndrome · ElevatedCryopyrin-Associated Periodic Syndromes · elevatedCryopyrin-Associated Periodic Syndromes · elevated
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Molecule2 diseases

Caspase-1

IL-1β converting enzyme

Schnitzler Syndrome · Constitutively activeCryopyrin-Associated Periodic Syndromes · elevated
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Molecule2 diseases

Gasdermin D

Membrane pore former

Schnitzler Syndrome · ActiveCryopyrin-Associated Periodic Syndromes · dysregulated
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Molecule2 diseases

IL-18

NK cell activator

Schnitzler Syndrome · ElevatedCryopyrin-Associated Periodic Syndromes · elevated
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Molecule2 diseases

IL-6

B-cell growth factor

Schnitzler Syndrome · ElevatedCryopyrin-Associated Periodic Syndromes · elevated
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Molecule2 diseases

NF-κB

Master transcription factor

Schnitzler Syndrome · Persistently activeCryopyrin-Associated Periodic Syndromes · elevated
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Molecule

ASC (PYCARD)

Inflammasome adaptor protein

Cryopyrin-Associated Periodic Syndromes · dysregulated
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Molecule

BTK

B-cell receptor kinase

Schnitzler Syndrome · Active
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Molecule

CCL2

Monocyte chemoattractant

Schnitzler Syndrome · Elevated
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Molecule

CRP

Acute phase protein

Cryopyrin-Associated Periodic Syndromes · elevated
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Molecule

Eosinophils

Effector granulocytes

Chronic Rhinosinusitis with Nasal Polyps · Massively infiltrated in tissue
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Molecule

Eotaxin-3 (CCL26)

Eosinophil chemoattractant

Chronic Rhinosinusitis with Nasal Polyps · Elevated
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Molecule

IgE

Allergic effector immunoglobulin

Chronic Rhinosinusitis with Nasal Polyps · Elevated (local and systemic)
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Molecule

IgM (monoclonal)

Diagnostic paraprotein

Schnitzler Syndrome · Present (obligate)
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Molecule

IL-13

Effector cytokine / tissue remodeller

Chronic Rhinosinusitis with Nasal Polyps · Elevated
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Molecule

IL-25

Epithelial alarmin

Chronic Rhinosinusitis with Nasal Polyps · Elevated
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Molecule

IL-33

Epithelial alarmin

Chronic Rhinosinusitis with Nasal Polyps · Elevated
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Molecule

IL-4

Type 2 master cytokine

Chronic Rhinosinusitis with Nasal Polyps · Elevated
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Molecule

IL-5

Eosinophil survival factor

Chronic Rhinosinusitis with Nasal Polyps · Elevated
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Molecule

ILC2s

Innate type 2 lymphoid cells

Chronic Rhinosinusitis with Nasal Polyps · Expanded in polyp tissue
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Molecule

MRP8/14 (S100A8/A9)

Neutrophil inflammatory markers

Schnitzler Syndrome · Elevated
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Molecule

MUC5AC

Gel-forming mucin

Chronic Rhinosinusitis with Nasal Polyps · Upregulated
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Molecule

MYD88

TLR signalling adaptor

Schnitzler Syndrome · L265P in ~30%
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Molecule

NLRP3

Inflammasome sensor

Schnitzler Syndrome · Dysregulated
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Molecule

NLRP3 (Cryopyrin)

Inflammasome sensor and scaffold

Cryopyrin-Associated Periodic Syndromes · mutated
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Molecule

Periostin

Extracellular matrix protein

Chronic Rhinosinusitis with Nasal Polyps · Elevated
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Molecule

S. aureus enterotoxins

Superantigen / disease perpetuator

Chronic Rhinosinusitis with Nasal Polyps · Present in polyp tissue
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Molecule

SAA (Serum Amyloid A)

Acute phase protein

Cryopyrin-Associated Periodic Syndromes · elevated
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Molecule

TNFα

Pro-inflammatory cytokine

Schnitzler Syndrome · Elevated
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Molecule

TSLP

Epithelial alarmin

Chronic Rhinosinusitis with Nasal Polyps · Elevated
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