Molecule
PKN1/PKN2
Pyrin phosphorylating kinases
- Expression change
- Normal (regulatory)
- Evidence level
- established
Role in pathogenesis
PKN1 and PKN2 are serine-threonine kinases activated by RhoA. They directly phosphorylate pyrin at Ser208 and Ser242, promoting 14-3-3 binding and keeping pyrin inactive. FMF-associated mutant pyrin shows substantially decreased binding to PKN and 14-3-3 proteins.