Molecule
IL-1beta (Interleukin-1 beta)
Pro-inflammatory cytokine elevated in POEMS
- Expression change
- Elevated
- Evidence level
- moderate
Role in pathogenesis
IL-1beta is part of the broad pro-inflammatory cytokine network elevated in POEMS. Gherardi et al. (1996) showed IL-1beta, TNF-alpha, and IL-6 are higher in POEMS than in multiple myeloma. The antagonistic response (IL-1ra elevation) is insufficient to counteract the pro-inflammatory drive. May contribute to neuropathy and systemic inflammation.