Each disease page is a deep, evidence-linked reference built from published research. More diseases are added based on community requests.
Rare acquired autoinflammatory disorder characterised by chronic urticarial rash with monoclonal IgM gammopathy and systemic inflammation. First described in 1972 by Liliane Schnitzler, the syndrome involves dysregulated IL-1β signalling driving fever, bone pain, arthralgia, and elevated inflammatory markers.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease of the sinonasal mucosa characterised by bilateral polyp growth, persistent nasal obstruction, anosmia, and impaired quality of life. Driven predominantly by type 2 inflammation — with IL-4, IL-5, IL-13, and IgE as key mediators — CRSwNP affects 1–4% of the general population and 20–30% of all chronic rhinosinusitis patients.
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