Molecule
14-3-3 proteins
Pyrin inhibitory chaperones
- Expression change
- Reduced binding to mutant pyrin
- Evidence level
- established
Role in pathogenesis
14-3-3 epsilon and tau bind to phosphorylated pyrin (at Ser208/Ser242), preventing inflammasome assembly. This binding is substantially decreased in FMF-associated mutant pyrin, contributing to constitutive inflammasome activation.