Molecule
Tryptase
Key diagnostic biomarker and mast cell mediator
- Expression change
- Elevated
- Evidence level
- established
Role in pathogenesis
Beta-tryptase is the most abundant mast cell granule protease. Basal serum tryptase >20 ng/mL is a minor WHO diagnostic criterion. Correlates with MC burden (r=0.8). Median 67 ng/mL in SM. Acute rises during degranulation episodes serve as anaphylaxis biomarker.