Molecule

Tryptase

Key diagnostic biomarker and mast cell mediator

Expression change
Elevated
Evidence level
established

Role in pathogenesis

Beta-tryptase is the most abundant mast cell granule protease. Basal serum tryptase >20 ng/mL is a minor WHO diagnostic criterion. Correlates with MC burden (r=0.8). Median 67 ng/mL in SM. Acute rises during degranulation episodes serve as anaphylaxis biomarker.

Sources (3)

DetailsAkin C et al. (2002) Serum tryptase levels in patients with mastocytosis: correlation with mast cell burden and implication for defining the category of diseaseDOI ↗
DetailsValent P et al. (2001) Diagnostic criteria and classification of mastocytosis: a consensus proposalDOI ↗
DetailsValent P et al. (2021) Updated Diagnostic Criteria and Classification of Mast Cell Disorders: A Consensus ProposalDOI ↗