Molecule3 diseases
Gasdermin D
Pore-forming protein
- Expression change
- dysregulated
- Evidence level
- strong
Expression across diseases
| Disease | Role | Expression | Evidence |
|---|---|---|---|
| Cryopyrin-Associated Periodic Syndromes | Pore-forming protein | dysregulated | strong |
| Familial Mediterranean Fever | Pyroptosis executor | Cleaved/activated | moderate |
| Schnitzler Syndrome | Membrane pore former | Active | emerging |
Role in pathogenesis
Cleaved by caspase-1 to form membrane pores; mediates pyroptosis and IL-1β/IL-18 release. Constitutive basal cleavage in CAPS mutant cells.