Molecule2 diseases
NLRP3
Inflammasome sensor
- Expression change
- Dysregulated
- Evidence level
- strong
Expression across diseases
| Disease | Role | Expression | Evidence |
|---|---|---|---|
| Schnitzler Syndrome | Inflammasome sensor | Dysregulated | strong |
| Cryopyrin-Associated Periodic Syndromes | Inflammasome sensor and scaffold | mutated | established |
Role in pathogenesis
NLRP3 assembles the inflammasome that activates caspase-1, which cleaves pro-IL-1β into active form. Unlike CAPS (gain-of-function mutation), no consistent NLRP3 mutation found.