Molecule
AKT / mTOR
Downstream effectors promoting MC proliferation and survival
- Expression change
- Constitutively activated
- Evidence level
- strong
Role in pathogenesis
AKT is phosphorylated by PI3K and activates mTOR, completing the STAT5-PI3K-AKT-mTOR cascade. mTORC1 is upregulated in neoplastic mast cells. Rapamycin blocks mTORC1 and inhibits D816V+ MC survival in vitro, though everolimus was ineffective clinically.