Molecule
TSLP
Epithelial alarmin
- Expression change
- Elevated
- Evidence level
- strong
- Targeted by
- Tezepelumab (investigational)
Role in pathogenesis
Released by damaged epithelial cells. Activates dendritic cells and ILC2s, initiating the type 2 cascade. An upstream target being investigated for CRSwNP therapy (tezepelumab).