Molecule
RhoA GTPase
Upstream guard target
- Expression change
- Normal (sensor target)
- Evidence level
- established
Role in pathogenesis
Pyrin functions as a guard for RhoA GTPase activity. When RhoA is inactivated by bacterial toxins, pyrin detects this as a danger signal. RhoA normally activates PKN1/PKN2 kinases that keep pyrin phosphorylated and inactive. The RhoA-PKN-pyrin axis is the central regulatory pathway disrupted in FMF.