Molecule

SAA (Serum Amyloid A)

Acute phase protein

Expression change
elevated
Evidence level
established
Targeted by
Normalized by IL-1 blockade

Role in pathogenesis

Chronically elevated in CAPS; precursor of AA amyloid deposits. Key treatment response biomarker. Normalization with IL-1 blockade reduces amyloidosis risk.

Sources (2)

H1Lachmann HJ et al. (2009) Use of canakinumab in the cryopyrin-associated periodic syndromePubMed ↗
G1Goldbach-Mansky R et al. (2006) Neonatal-onset multisystem inflammatory disease responsive to interleukin-1β inhibitionPubMed ↗