Molecule

HCK

SRC family kinase transactivated by mutated MYD88

Expression change
Upregulated
Evidence level
moderate

Role in pathogenesis

Mutated MYD88 triggers HCK gene expression through PAX5-mediated signaling. HCK is activated via IL-6/IL-6R/gp130/JAK2/STAT3 signaling and triggers BTK, SYK, and ERK1/2 cascades, providing an additional layer of pro-survival signaling.

Sources (2)

DetailsBibas M et al. (2024) WM: State-of-the-Art Review Part 1 - Epidemiology, Pathogenesis, ClinicalDOI ↗
DetailsTreon SP et al. (2024) How I use genomics and BTK inhibitors in the treatment of WMDOI ↗