Molecule2 diseases
CCL2
Monocyte chemoattractant
- Expression change
- Elevated
- Evidence level
- moderate
Expression across diseases
| Disease | Role | Expression | Evidence |
|---|---|---|---|
| Schnitzler Syndrome | Monocyte chemoattractant | Elevated | moderate |
| Chronic Rhinosinusitis with Nasal Polyps | Eosinophil chemoattractant | Elevated | strong |
Role in pathogenesis
Elevated in patient serum. Produced by PBMCs and dermal fibroblasts upon IL-1β stimulation. Recruits mononuclear cells to skin and bone.
Sources (1)
B3Regnault V et al. (2019) PBMC studies: spontaneous IL-1β release