Molecule

CRP

Acute phase protein

Expression change
elevated
Evidence level
established
Targeted by
Normalized by IL-1 blockade

Role in pathogenesis

Universally elevated during CAPS flares. Primary biomarker for treatment monitoring; target <10 mg/L under IL-1 blockade.

Sources (2)

A2Kuemmerle-Deschner JB et al. (2017) Diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS)PubMed ↗
H1Lachmann HJ et al. (2009) Use of canakinumab in the cryopyrin-associated periodic syndromePubMed ↗