Molecule
IL-33
Epithelial alarmin
- Expression change
- Elevated
- Evidence level
- strong
- Targeted by
- Itepekimab (investigational anti-IL-33)
Role in pathogenesis
Released from necrotic epithelial cells. Binds ST2 receptor on ILC2s and Th2 cells, powerfully amplifying IL-5 and IL-13 production. A key upstream driver of type 2 inflammation.