Molecule3 diseases
NF-κB
Transcription factor
- Expression change
- elevated
- Evidence level
- established
Expression across diseases
| Disease | Role | Expression | Evidence |
|---|---|---|---|
| Cryopyrin-Associated Periodic Syndromes | Transcription factor | elevated | established |
| Schnitzler Syndrome | Master transcription factor | Persistently active | strong |
| TNF Receptor-Associated Periodic Syndrome | Transcription factor — inflammatory amplifier | Constitutively activated | established |
Role in pathogenesis
Activated constitutively; drives transcription of pro-IL-1β and NLRP3 itself, creating feed-forward loop that amplifies the inflammatory signal.
Sources (2)
DetailsMolina-López C et al. (2024) Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β productionDOI ↗
DetailsMoltrasio C et al. (2022) NLRP3 inflammasome and NLRP3-related autoinflammatory diseases: from cryopyrin function to targeted therapies