Molecule

IL-25

Epithelial alarmin

Expression change
Elevated
Evidence level
moderate

Role in pathogenesis

Third epithelial alarmin. Activates ILC2s and Th2 cells. Works synergistically with IL-33 and TSLP to sustain type 2 inflammation.

Sources (1)

DetailsNagarkar DR et al. (2013) Airway epithelial alarmins in CRSwNP: IL-33, IL-25, and TSLPDOI