Molecule
Periostin
Extracellular matrix protein
- Expression change
- Elevated
- Evidence level
- moderate
Role in pathogenesis
Produced by epithelial cells and fibroblasts under IL-4/IL-13 stimulation. Promotes eosinophil adhesion and tissue remodelling. Potential biomarker for type 2 inflammation severity.
Sources (1)
P2Bachert C et al. (2015) Endotype-driven care pathways in patients with chronic rhinosinusitisDOI ↗