Molecule2 diseases
ASC (PYCARD)
Inflammasome adaptor protein
- Expression change
- dysregulated
- Evidence level
- established
Expression across diseases
| Disease | Role | Expression | Evidence |
|---|---|---|---|
| Cryopyrin-Associated Periodic Syndromes | Inflammasome adaptor protein | dysregulated | established |
| Familial Mediterranean Fever | Inflammasome adaptor protein | Essential for pyrin inflammasome | established |
Role in pathogenesis
Adaptor protein forming ASC specks that bridge NLRP3 sensor to caspase-1 effector. Spontaneous ASC speck formation observed in CAPS monocytes without signal 2 stimulation.