Molecule
ASC (PYCARD)
Inflammasome adaptor protein
- Expression change
- dysregulated
- Evidence level
- established
Role in pathogenesis
Adaptor protein forming ASC specks that bridge NLRP3 sensor to caspase-1 effector. Spontaneous ASC speck formation observed in CAPS monocytes without signal 2 stimulation.
Sources (2)
B7Tassi S et al. (2010) Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1β secretionPubMed ↗
B2Molina-López C et al. (2024) Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β productionPubMed ↗