significantNew research

French national series quantifies AA amyloidosis severity in TRAPS

TNF Receptor-Associated Periodic Syndrome

Summary

Delaleu et al. (2021) reported that AA amyloidosis preceded TRAPS diagnosis in 96% of cases, with 47% needing renal replacement therapy and 14% mortality. Highlights the importance of early TRAPS diagnosis.

Source

Grade Bcase series and review

Tumour necrosis factor receptor-1 associated periodic syndrome (TRAPS)-related AA amyloidosis: a national case series and systematic review

Delaleu J, Deshayes S, Rodrigues F, Savey L, Rivière E, Martin Silva N, Aouba A, Amselem S, Rabant M, Grateau G, Giurgea I, Georgin-Lavialle S · Rheumatology (Oxford) · 2021

  • AA amyloidosis preceded TRAPS diagnosis in 96% of cases
  • 47% required renal replacement therapy
  • 14% mortality after median 23-month follow-up

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ID: traps-update-2Type: new_researchImpact: significant