significantGenetic finding

INSAID classification system validated for TRAPS treatment decisions

TNF Receptor-Associated Periodic Syndrome

Summary

Papa et al. (2021) demonstrated that INSAID variant classification (Groups A/B/C) combined with Eurofever criteria reliably predicts treatment needs in 226 TRAPS patients. Anti-IL-1 drugs achieved >85% complete response in Group A.

Source

Grade Bcohort

INSAID variant classification and Eurofever criteria guide optimal treatment strategy in patients with TRAPS: data from the Eurofever Registry

Papa R, Lane T, Minden K, Touitou I, Cantarini L, Cattalini M, Obici L, et al. · J Allergy Clin Immunol Pract · 2021

  • 226 patients classified by INSAID: Group A (pathogenic) 56%, Group B (uncertain) 35%, Group C (benign) 9%
  • Anti-IL-1 drugs achieved >85% complete response in patients meeting Eurofever criteria
  • No patients on anti-IL-1 treatment developed AA amyloidosis

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ID: traps-update-1Type: genetic_findingImpact: significant