INSAID variant classification and Eurofever criteria guide optimal treatment strategy in patients with TRAPS: data from the Eurofever Registry

Papa R, Lane T, Minden K, Touitou I, Cantarini L, Cattalini M, Obici L, et al.

J Allergy Clin Immunol Pract · 2021

Grade Bcohortn=226

Key Findings

  • 226 patients classified by INSAID: Group A (pathogenic) 56%, Group B (uncertain) 35%, Group C (benign) 9%
  • Anti-IL-1 drugs achieved >85% complete response in patients meeting Eurofever criteria
  • No patients on anti-IL-1 treatment developed AA amyloidosis
  • 16% of Group A patients developed AA amyloidosis

Referenced in (1 disease)

ID: pmid-33181346DOI: 10.1016/j.jaip.2020.09.060PMID: 33181346