Drug1st line2 diseases
NSAIDs
Cyclooxygenase inhibition; anti-inflammatory and antipyretic
- Response rate
- <20%
- Onset
- Days
- Route
- Oral (various)
- Line
- 1st
- IgM effect
- No direct effect
- Evidence level
- amber
Used across diseases
| Disease | Response rate | Line | Evidence |
|---|---|---|---|
| Adult-Onset Still's Disease | <20% | 1st | amber |
| Cryopyrin-Associated Periodic Syndromes | Symptomatic only | Supportive | red |
Evidence summary
First-line for mild disease (fever, arthralgia, myalgia) but effective as monotherapy in fewer than 20% of patients. Most patients require escalation to corticosteroids. Aspirin and indomethacin historically used. Risk of hepatotoxicity in AOSD patients with liver involvement.