NSAIDs
Cyclooxygenase inhibition; anti-inflammatory and antipyretic
- Response rate
- <20%
- Onset
- Days
- Route
- Oral (various)
- Line
- 1st
- IgM effect
- No direct effect
Evidence summary
First-line for mild disease (fever, arthralgia, myalgia) but effective as monotherapy in fewer than 20% of patients. Most patients require escalation to corticosteroids. Aspirin and indomethacin historically used. Risk of hepatotoxicity in AOSD patients with liver involvement.