ASC (PYCARD)

Inflammasome adaptor protein

Expression: dysregulated
Evidence level: established

Role in pathogenesis

Adaptor protein forming ASC specks that bridge NLRP3 sensor to caspase-1 effector. Spontaneous ASC speck formation observed in CAPS monocytes without signal 2 stimulation.

Sources (2)

DetailsTassi S et al. (2010) Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1β secretion · Proc Natl Acad Sci USAPubMed ↗

DetailsMolina-López C et al. (2024) Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production · Nat CommunDOI ↗