TSLP
Genetic findings for TSLP in Chronic Rhinosinusitis with Nasal Polyps
Variants (1)
| Variant | Type | Frequency | Significance |
|---|---|---|---|
| Regulatory SNPs | germline | Associated in multiple GWAS | TSLP variants influence epithelial alarmin production. TSLP activates dendritic cells to drive Th2 polarisation and directly activates ILC2s. |
Clinical implications
Regulatory SNPs
Supports epithelial-driven disease model. Tezepelumab (anti-TSLP) is in clinical trials for CRSwNP.
Also found in: Asthma (Well-established), Eosinophilic esophagitis (Associated)
Related molecules
TSLPstrong
Epithelial alarmin — Elevated
Related hypotheses
Epigenetic reprogramming by environmental exposures shapes disease susceptibility
30emerging·25 studies
Sources (1)
G2Portelli MA et al. (2020) Genetic risk factors for CRSwNP: IL-33/ST2 and TSLP pathway variants · J Allergy Clin ImmunolDOI ↗