Gene
TSLP
1 variant(s) documented across Chronic Rhinosinusitis with Nasal Polyps
Variants
| Variant | Type | Frequency in disease | Significance | Also found in |
|---|---|---|---|---|
| Regulatory SNPs | germline | Associated in multiple GWAS | TSLP variants influence epithelial alarmin production. TSLP activates dendritic cells to drive Th2 polarisation and directly activates ILC2s. | Asthma (Well-established); Eosinophilic esophagitis (Associated) |
Clinical implications
Regulatory SNPs
Supports epithelial-driven disease model. Tezepelumab (anti-TSLP) is in clinical trials for CRSwNP.
Testing: GWAS
Related molecules in pathway
TSLPstrong
Epithelial alarmin — Elevated
Related hypotheses
Epigenetic reprogramming by environmental exposures shapes disease susceptibility
30emerging·25 studies
Sources (1)
G2Portelli MA et al. (2020) Genetic risk factors for CRSwNP: IL-33/ST2 and TSLP pathway variantsDOI ↗