Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome

Broderick L, Hoffman HM

J Exp Med · 2021

Key Findings

  • Neutrophils identified as key cellular source of IL-1β in CAPS
  • Neutrophil-specific knock-in mice develop CAPS

Referenced in (1 disease)

Validation history

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  1. passsource metadataJun 1, 2026, 01:59 PMby pubmed-api

    PMID/DOI resolved and recorded from PubMed E-utilities during SEO DOI backfill.

    tools: pubmed.esummary

ID: pmid-34477811DOI: 10.1084/jem.20201466PMID: 34477811