incrementalDiagnostic advance
Proposed diagnostic algorithm integrating anti-C1q titers with complement levels
Hypocomplementemic Urticarial Vasculitis Syndrome →Summary
A 2019 consensus proposal recommended a stepwise diagnostic algorithm for suspected HUVS: urticarial lesion biopsy showing leukocytoclastic vasculitis, followed by anti-C1q antibody testing and C3/C4/CH50 measurement. Anti-C1q titers above 30 U/mL combined with low C1q and C4 showed 92% diagnostic specificity for HUVS versus other urticarial vasculitis subtypes.
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ID: hypocomplementemic-urticarial-vasculitis-syndrome-update-7Type: diagnostic_advanceImpact: incremental