significantMechanism
Gasdermin D and pyroptosis established as central to AOSD cytokine storm
Adult-Onset Still's Disease →Summary
Multiple studies identified gasdermin D-mediated pyroptosis as the dominant cell death pathway in AOSD, linking NLRP3 inflammasome activation to IL-1 beta and IL-18 release. Elevated gasdermin D cleavage products in AOSD serum correlate with disease activity, positioning pyroptosis inhibition as a novel therapeutic strategy.
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