incrementalMechanism
Neutrophil extracellular traps (NETs) identified in AOSD pathogenesis
Adult-Onset Still's Disease →Summary
Research revealed that neutrophils in AOSD patients have enhanced capacity to form NETs, which activate pro-inflammatory macrophages and further stimulate the NLRP3 inflammasome. This creates a self-amplifying loop that helps explain the explosive cytokine storm characteristic of AOSD flares and MAS.
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significantnew treatment
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ID: adult-onset-stills-disease-update-2Type: mechanismImpact: incremental