significantDiagnostic advance
Free IL-18 established as AOSD-specific biomarker
Adult-Onset Still's Disease →Summary
Studies demonstrated that free (unbound) IL-18 is specifically elevated in AOSD compared to other inflammatory diseases, with levels up to 1000-fold higher than controls. Unlike total IL-18, free IL-18 distinguishes AOSD from infections, malignancies, and other autoimmune conditions, supporting its potential integration into classification criteria and as a therapeutic target.
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ID: adult-onset-stills-disease-update-1Type: diagnostic_advanceImpact: significant