Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS
Park YH, Wood G, Kastner DL, Chae JJ
Nat Immunol · 2016
Grade Abasic research
Key Findings
- ●RhoA activates PKN1/PKN2 which phosphorylate pyrin at Ser208 and Ser242
- ●Phosphorylated pyrin binds 14-3-3 proteins keeping inflammasome inactive
- ●FMF mutations decrease PKN/14-3-3 binding
Referenced in (1 disease)
ID: pmid-27270401DOI: 10.1038/ni.3457PMID: 27270401