Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome

Gherardi RK, Belec L, Soubrier M, et al.

Blood · 1996

Grade Bcohortn=15
PubMed ↗

Key Findings

  • ●IL-1beta, TNF-alpha, IL-6 elevated in POEMS vs myeloma
  • ●TGF-beta1 decreased — weak antagonistic reaction
  • ●Proinflammatory cytokine network drives disease manifestations

Referenced in (1 disease)

POEMS Syndrome
ID: pmid-8608236PMID: 8608236