DrugRescue line
Oral corticosteroids (short course)
Systemic anti-inflammatory
- Response rate
- Rapid polyp shrinkage
- Onset
- Days
- Route
- Oral prednisone 25–50mg, 5–14 day taper
- Line
- Rescue
- IgM effect
- Rapid temporary reduction
- Evidence level
- amber
Evidence summary
Rapid but temporary polyp reduction. EPOS 2020 recommends limiting to 1–2 courses per year due to cumulative toxicity (osteoporosis, diabetes, adrenal suppression, cataracts). Frequent need for oral steroids is an indication for biologic therapy.