DrugSupportive line3 diseases

Corticosteroids

Broad anti-inflammatory

Response rate
Partial, temporary
Onset
Days
Route
Oral
Line
Supportive
IgM effect
Partial reduction
Evidence level
red

Used across diseases

DiseaseResponse rateLineEvidence
Cryopyrin-Associated Periodic SyndromesPartial, temporarySupportivered
Schnitzler SyndromeTemporary, partialNot recommendedred
TNF Receptor-Associated Periodic SyndromeEffective for acute attacks; not for long-termAlternativeamber

Evidence summary

Provide temporary partial symptom relief but do not prevent organ damage or normalize inflammatory markers long-term. Significant side effects with chronic use. Not recommended as primary therapy.

Sources (2)

DetailsKuemmerle-Deschner JB (2015) CAPS—pathogenesis, presentation and treatment of an autoinflammatory diseasePubMed
DetailsWelzel T et al. (2021) Diagnosis and management of the cryopyrin-associated periodic syndromes (CAPS): what do we know today?