NF-kB
Transcription factor driving B-cell survival
- Expression
- Constitutively activated
- Evidence level
- established
Role in pathogenesis
NF-kB is the convergent downstream target of both MYD88-IRAK and MYD88-BTK signaling arms. Constitutive NF-kB activation drives B-cell survival, proliferation, and IgM secretion. Loss of TNFAIP3 (A20) via 6q deletion in ~50% of patients further amplifies NF-kB activity.