NF-kB

Transcription factor driving B-cell survival

Expression
Constitutively activated
Evidence level
established

Role in pathogenesis

NF-kB is the convergent downstream target of both MYD88-IRAK and MYD88-BTK signaling arms. Constitutive NF-kB activation drives B-cell survival, proliferation, and IgM secretion. Loss of TNFAIP3 (A20) via 6q deletion in ~50% of patients further amplifies NF-kB activity.

Sources (3)

DetailsBibas M et al. (2024) WM: State-of-the-Art Review Part 1 - Epidemiology, Pathogenesis, Clinical · Mediterr J Hematol Infect DisDOI ↗
DetailsTreon SP et al. (2018) Insights into the genomic landscape of MYD88 wild-type WM · BloodDOI ↗
DetailsTreon SP et al. (2012) MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia · N Engl J MedDOI ↗