NF-κB
Transcription factor — inflammatory amplifier
- Expression
- Constitutively activated
- Evidence level
- established
Role in pathogenesis
ER-retained mutant TNFR1 constitutively activates NF-κB signalling, driving transcription of pro-inflammatory cytokines including IL-1β, IL-6, and TNF-α. NF-κB activation occurs via both canonical and non-canonical pathways.