MAPK pathway
Signalling cascade — enhanced by mutant TNFR1
- Expression
- Hyperactivated
- Evidence level
- strong
Role in pathogenesis
MAPK phosphorylation is enhanced in TRAPS patient cells upon LPS stimulation. Mitochondrial ROS drive increased MAPK activation, which in turn promotes pro-inflammatory cytokine production. This represents a TNF-independent mechanism of inflammation.