MAPK pathway

Signalling cascade — enhanced by mutant TNFR1

Expression
Hyperactivated
Evidence level
strong

Role in pathogenesis

MAPK phosphorylation is enhanced in TRAPS patient cells upon LPS stimulation. Mitochondrial ROS drive increased MAPK activation, which in turn promotes pro-inflammatory cytokine production. This represents a TNF-independent mechanism of inflammation.

Sources (2)

DetailsBulua AC et al. (2011) Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) · J Exp MedDOI ↗
DetailsSimon A et al. (2010) Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome · Proc Natl Acad Sci USADOI ↗