Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

Key Findings

• ●Elevated mitochondrial ROS in TRAPS patient cells and mutant mouse models
• ●Mitochondrial ROS drive enhanced LPS-induced MAPK phosphorylation and cytokine production
• ●Antioxidants reduce inflammatory cytokine output — potential therapeutic target

Referenced in (1 disease)