STAT5
Key transcription factor in KIT D816V signaling
- Expression
- Constitutively phosphorylated
- Evidence level
- strong
Role in pathogenesis
STAT5 is constitutively activated by KIT D816V and localizes to the cytoplasm to form a signaling complex with PI3K. Knockdown of STAT5 inhibits neoplastic mast cell growth. Essential mediator of the STAT5-PI3K-AKT cascade.