NF-κB
Master transcription factor
- Expression
- Persistently active
- Evidence level
- strong
- Targeted by
- Bortezomib (indirect)
Role in pathogenesis
Convergence point — both NLRP3/IL-1β and MYD88 pathways activate NF-κB, which drives inflammatory cytokine production.
Targeting drugs (1)
| Drug | Mechanism | Response | Line |
|---|---|---|---|
| Bortezomib | Proteasome inhibitor (NF-κB pathway) | Single case report | Investigational |