ASC (PYCARD)
Inflammasome adaptor protein
- Expression
- Essential for pyrin inflammasome
- Evidence level
- established
Role in pathogenesis
ASC is the critical adaptor protein that bridges pyrin to caspase-1. The pyrin inflammasome is ASC-dependent — ASC-deficient mice crossed with FMF knock-in mice show complete ablation of inflammation. Pyrin's N-terminal PYD domain interacts with ASC's PYD domain.