Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1beta activation and severe autoinflammation in mice

Key Findings

• ●Pyrin inflammasome is ASC-dependent but NLRP3-independent
• ●FMF knock-in mice show spontaneous inflammation ablated by IL-1R deficiency
• ●Provides evidence for distinct pyrin inflammasome in FMF

Referenced in (1 disease)