NF-κB
Transcription factor
- Expression
- elevated
- Evidence level
- established
Role in pathogenesis
Activated constitutively; drives transcription of pro-IL-1β and NLRP3 itself, creating feed-forward loop that amplifies the inflammatory signal.
Sources (2)
B2Molina-López C et al. (2024) Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production · Nat CommunPubMed ↗
B6Moltrasio C et al. (2022) NLRP3 inflammasome and NLRP3-related autoinflammatory diseases: from cryopyrin function to targeted therapies · Front Immunol