Gasdermin D

Pore-forming protein

Expression
dysregulated
Evidence level
strong

Role in pathogenesis

Cleaved by caspase-1 to form membrane pores; mediates pyroptosis and IL-1β/IL-18 release. Constitutive basal cleavage in CAPS mutant cells.

Sources (1)

DetailsMolina-López C et al. (2024) Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production · Nat CommunDOI ↗