Gasdermin D
Pore-forming protein
- Expression
- dysregulated
- Evidence level
- strong
Role in pathogenesis
Cleaved by caspase-1 to form membrane pores; mediates pyroptosis and IL-1β/IL-18 release. Constitutive basal cleavage in CAPS mutant cells.
Sources (1)
B2Molina-López C et al. (2024) Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production · Nat CommunPubMed ↗