Periostin

Extracellular matrix protein

Expression: Elevated
Evidence level: moderate

Role in pathogenesis

Produced by epithelial cells and fibroblasts under IL-4/IL-13 stimulation. Promotes eosinophil adhesion and tissue remodelling. Potential biomarker for type 2 inflammation severity.

Sources (1)

P2Bachert C et al. (2015) Endotype-driven care pathways in patients with chronic rhinosinusitis · J Allergy Clin ImmunolDOI ↗