IL-25
Epithelial alarmin
- Expression
- Elevated
- Evidence level
- moderate
Role in pathogenesis
Third epithelial alarmin. Activates ILC2s and Th2 cells. Works synergistically with IL-33 and TSLP to sustain type 2 inflammation.
Sources (1)
P4Nagarkar DR et al. (2013) Airway epithelial alarmins in CRSwNP: IL-33, IL-25, and TSLP · J Allergy Clin ImmunolDOI ↗