Epigenetic modifications
Genetic findings for Epigenetic modifications in Chronic Rhinosinusitis with Nasal Polyps
Variants (1)
| Variant | Type | Frequency | Significance |
|---|---|---|---|
| DNA methylation changes at IL-13, IL-5, FOXP3 loci | unknown | Broadly observed in polyp tissue | Hypomethylation at type 2 cytokine loci and hypermethylation at regulatory T-cell loci (FOXP3) in polyp tissue. Suggests environmental epigenetic programming may be more important than germline variants. |
Clinical implications
DNA methylation changes at IL-13, IL-5, FOXP3 loci
May explain environmental risk factors. Epigenetic therapies are a future possibility.
Related hypotheses
Epigenetic reprogramming by environmental exposures shapes disease susceptibility
30emerging·25 studies
Sources (1)
G5Cardenas A et al. (2019) Epigenomic profiling of nasal polyp tissue reveals type 2 inflammation signatures · J Allergy Clin ImmunolDOI ↗